Understanding Wellbutrin Addiction: Is Wellbutrin Addictive?

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Wellbutrin is a prescription drug that can become addictive if misused. Wellbutrin, also known by its generic name bupropion, is a commonly prescribed medication for treating depression, seasonal affective disorder (SAD), and nicotine addiction. While it can be highly effective for these conditions when used as directed by a medical professional, it is essential to be aware of the potential for Wellbutrin addiction. In this article, we will explore what Wellbutrin is, how it works, the history of the medication, potential side effects, the signs and dangers of Wellbutrin addiction, and available treatment options.

What is Wellbutrin?

Wellbutrin is the brand name for the medication bupropion. It is an atypical antidepressant that is used to treat major depressive disorder, seasonal affective disorder (SAD), and help people quit smoking by reducing withdrawal symptoms and cravings.

Wellbutrin helps balance out the chemicals in the brain. It can be taken in different forms like extended-release, sustained-release, or immediate-release tablets, and simply swallowed.

When Wellbutrin is used as prescribed for medical reasons, the risk of addiction is pretty low. But if someone takes much more than they should, they might experience a high, somewhat like what you'd get from cocaine. Wellbutrin abuse and addiction is becoming more and more common.

You'll find Wellbutrin under various brand names, such as:

  • Wellbutrin
  • Aplenzin
  • Zyban

With its wide range of uses and effectiveness, Wellbutrin has become a valuable tool in the world of mental health and addiction treatment. At the same time, its widespread use makes it more easily accessible and ups the dependency and addiction rate.

How Wellbutrin Works

Under the name Zyban, bupropion has proven effective in helping individuals quit smoking. The best part about Zyban is that you don't need to have depression or its symptoms to receive a prescription. Zyban doesn't contain nicotine, but it's a valuable ally in the fight against tobacco addiction. It helps reduce cravings for tobacco and makes the discomfort of nicotine withdrawal more manageable.

Wellbutrin's primary mechanism of action involves regulating two crucial neurotransmitters in the brain: norepinephrine and dopamine. These neurotransmitters are responsible for mood regulation and motivation.

Wellbutrin “inhibits the reuptake” of these neurotransmitters, which means it prevents the brain from recycling them too quickly. This inhibition allows norepinephrine and dopamine to remain active in the brain for longer periods. This results in improved mood and reduced cravings, particularly for nicotine – making Zyban valuable for those looking to quit smoking. In essence, Wellbutrin helps maintain the balance of essential brain chemicals, leading to enhanced mood and reduced cravings.

For an even better chance at success, those planning to use Zyban to quit smoking can consider combining it with other nicotine replacement methods, such as nicotine gum, inhalers, or patches. These additional tools work in tandem with Zyban, creating a multi-pronged approach to enhance the journey to a smoke-free life. 

Wellbutrin Addiction 

Antidepressants like Wellbutrin are among the top three medications prescribed in the United States. While some individuals may take them for only a few weeks, others continue their use for years, and in some cases, this extended use can lead to dependence on the effects they provide.

While Wellbutrin is generally safe for use under the direct supervision of a doctor, some individuals have found ways to misuse it recreationally. Typically, Wellbutrin tablets are designed to be swallowed whole. However, those who abuse Wellbutrin often resort to chewing the pills or crushing them to snort the resulting powder. In some cases, they may even dissolve the powder in water and inject it, although this method carries significant risks, including infection and damage to blood vessels, among other dangers.

Misuse of Wellbutrin in these ways allows individuals to bypass the sustained or extended-release properties of the drug. Consequently, the brain experiences a sudden rush of neurotransmitters, resulting in stimulant effects.

Can You Get High on Wellbutrin? 

Some people abuse Wellbutrin by taking very large doses in an attempt to achieve a high. Misusing Wellbutrin, whether by crushing wellbutrin, snorting wellbutrin or taking excessive doses, can cause harmful and dangerous side effects. Such misuse also increases the risk of developing tolerance, dependence, and addiction over time.

Signs and Dangers of Wellbutrin Addiction

Bupropion (Wellbutrin) addiction is becoming more and more common, and it's important to know what to look out for. Individuals with a history of prescription drug abuse or drug and alcohol addiction may be at a higher risk of developing Wellbutrin addiction. Many cocaine users turn to abusing bupropion (Wellbutrin) when unable to obtain cocaine, seeking an affordable alternative that is readily available.

If someone is struggling with Wellbutrin addiction, there are telltale behaviors to be vigilant about. Signs and symptoms of Wellbutrin addiction often include:

  • Staying awake for extended periods or experiencing difficulty sleeping.
  • Heightened energy levels and increased activity.
  • Loss of appetite.
  • Excessive excitement, happiness, or elation.
  • A sudden boost in self-esteem.
  • Prescription shopping - seeking multiple prescriptions for bupropion (Wellbutrin) from different doctors.

While Wellbutrin is generally safe when used as prescribed and under the supervision of a healthcare professional, its misuse can lead to a range of physical and psychological dangers. Individuals who have developed Wellbutrin addiction may face a challenging road to recovery and should seek professional help to address their condition. Misuse of this medication can result in tolerance, dependence, and addiction, emphasizing the importance of responsible and monitored use.

Wellbutrin Side Effects 

Like any medication, Wellbutrin is associated with potential side effects. These can include:

  • Insomnia
  • Dry mouth
  • Nausea
  • Headaches
  • Weight loss

How long do wellbutrin side effects last?

Wellbutrins side effects take anywhere between a few days and several weeks to go away. However, if side effects persist or worsen, it is advisable to talk to a doctor. 


Abusing Wellbutrin can also lead to dangerous side effects, and there have been documented cases of bupropion overdose, stemming from intentional abuse, suicide attempts, and accidental poisoning. The effects of a Wellbutrin overdose can be profound and alarming, including:

  • Agitation
  • Vertigo
  • Involuntary muscle contractions
  • Tachycardia (rapid heart rate)
  • Hallucinations
  • Seizures

The likelihood of seizures occurring increases with the dose of bupropion ingested, making this a particularly dangerous side effect for abusers. In severe cases, Wellbutrin overdose has proven to be fatal.

Injection use of Wellbutrin poses especially high risks. Bupropion pills contain ingredients not intended for injection, and abusing the drug intravenously can lead to severe side effects, such as skin lesions, blood vessel damage, and, tragically, even death.

Wellbutrin Withdrawal

In addition to the physical risks associated with Wellbutrin abuse, some people have reported experiencing withdrawal symptoms when they stopped taking the drug, including irritability and depressed mood. As with any potentially addictive substance, abusers may prioritize obtaining and using Wellbutrin over other essential aspects of life, such as work responsibilities and maintaining relationships with family and friends.

History of Wellbutrin 

Bupropion, the active ingredient in Wellbutrin, has an interesting history. It was patented by GlaxoSmithKline (formerly Burroughs-Wellcome) in 1974 and received FDA approval in 1985. However, early usage at doses of 400-600 mg led to concerns about seizures, resulting in its temporary withdrawal in 1986.

A breakthrough came in 1996 with the introduction of a sustained-release tablet, marketed as Zyban. In 2003, Wellbutrin XL, an extended-release version requiring once-a-day dosing, was introduced. This improved convenience and reduced the risk of seizures to levels similar to other antidepressants.

Wellbutrin Addiction Treatment

Withdrawal symptoms during Wellbutrin detox are typically milder compared to other antidepressants, given its limited impact on serotonin levels. However, individuals addicted to Wellbutrin may encounter withdrawal symptoms if they suddenly cease using it. These can include irritability, extreme agitation, hostile behavior, and, at times, even suicidal thoughts.

While Wellbutrin detox is generally associated with less severe withdrawal symptoms, seeking professional guidance during this phase is a wise choice. It ensures that any potential issues, including suicidal thoughts, are managed expertly. Medical detox programs for Wellbutrin addiction gradually taper the person's bupropion dose, making the withdrawal process safer and more comfortable.

Upon completing Wellbutrin detox, individuals may explore additional treatment options, such as rehab or sober living programs, to continue their journey to addiction recovery. These programs offer structured and supportive environments, providing the necessary tools and resources for long-term well-being.

Wellbutrin is a valuable medication for the treatment of depression and smoking cessation, but it is not without its potential for misuse and addiction. Understanding the medication, its mechanisms, and the signs of Wellbutrin addiction is essential for preventing and addressing this issue.

Avenues Recovery Can Help You Recover From Wellbutrin Addiction

If you or a loved one are struggling with Wellbutrin addiction or any substance use disorder, remember that help is available. Avenues Recovery Center is dedicated to providing compassionate, personalized addiction treatment. We offer a range of evidence-based therapies, a supportive community, and experienced professionals to guide you towards the path of recovery. Our staff are experts in the field of addiction and have helped thousands of people turn their lives around. Take that first step towards a healthier, happier life today. Contact Avenues and let us start you on your journey to lasting recovery. Remember that there's hope, and you don't have to face addiction alone!

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